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chk2 inhibitor bml 277  (MedChemExpress)


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    MedChemExpress chk2 inhibitor bml 277
    Chk2 Inhibitor Bml 277, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/chk2+inhibitor+bml+277/pm41980094-269-22-45?v=MedChemExpress
    Average 93 stars, based on 8 article reviews
    chk2 inhibitor bml 277 - by Bioz Stars, 2026-08
    93/100 stars

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    chk2 inhibitor  (MedChemExpress)
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    NPM1 redistribution with Chk1 and <t>Chk2</t> inhibition at 24 h drug treatment. Cells were treated with 10 μM platinum compounds or 5 nM of ActD for 24 h in the presence or absence of Chk1i (1.0 mM) or Chk2i (0.4 μM) in A549 ( A ) or U-2 OS ( B ) cell lines. NPM1 immunofluorescence distribution was then quantified . Each point is the average CV value and SD for three biological replicates. Representative cell images of cells treated with 1 or 2 in the presence of Chk1i, Chk2i, or no inhibitor for each cell line are shown with NPM1 ( green ). ∗∗∗ p < 0.001, ns = p > 0.1.
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    NPM1 redistribution with Chk1 and <t>Chk2</t> inhibition at 24 h drug treatment. Cells were treated with 10 μM platinum compounds or 5 nM of ActD for 24 h in the presence or absence of Chk1i (1.0 mM) or Chk2i (0.4 μM) in A549 ( A ) or U-2 OS ( B ) cell lines. NPM1 immunofluorescence distribution was then quantified . Each point is the average CV value and SD for three biological replicates. Representative cell images of cells treated with 1 or 2 in the presence of Chk1i, Chk2i, or no inhibitor for each cell line are shown with NPM1 ( green ). ∗∗∗ p < 0.001, ns = p > 0.1.
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    NPM1 redistribution with Chk1 and Chk2 inhibition at 24 h drug treatment. Cells were treated with 10 μM platinum compounds or 5 nM of ActD for 24 h in the presence or absence of Chk1i (1.0 mM) or Chk2i (0.4 μM) in A549 ( A ) or U-2 OS ( B ) cell lines. NPM1 immunofluorescence distribution was then quantified . Each point is the average CV value and SD for three biological replicates. Representative cell images of cells treated with 1 or 2 in the presence of Chk1i, Chk2i, or no inhibitor for each cell line are shown with NPM1 ( green ). ∗∗∗ p < 0.001, ns = p > 0.1.

    Journal: The Journal of Biological Chemistry

    Article Title: The unique Pt(II)-induced nucleolar stress response and its deviation from DNA damage response pathways

    doi: 10.1016/j.jbc.2024.107858

    Figure Lengend Snippet: NPM1 redistribution with Chk1 and Chk2 inhibition at 24 h drug treatment. Cells were treated with 10 μM platinum compounds or 5 nM of ActD for 24 h in the presence or absence of Chk1i (1.0 mM) or Chk2i (0.4 μM) in A549 ( A ) or U-2 OS ( B ) cell lines. NPM1 immunofluorescence distribution was then quantified . Each point is the average CV value and SD for three biological replicates. Representative cell images of cells treated with 1 or 2 in the presence of Chk1i, Chk2i, or no inhibitor for each cell line are shown with NPM1 ( green ). ∗∗∗ p < 0.001, ns = p > 0.1.

    Article Snippet: ATM inhibitor (KU-55933, MedChemExpress) treatment was conducted at 10 μM, ATR inhibitor (AZD6738, MedChemExpress) treatment was conducted at 2.5 μM, Chk1 inhibitor (caffeine) treatment was conducted at 1 mM, and Chk2 inhibitor (BML-277, MedChemExpress) treatment was conducted at 0.4 μM.

    Techniques: Inhibition, Immunofluorescence